Anti-Acetyl-Histone H2A (Lys9) Rabbit mAb

PTM BIO

Anti-Acetyl-Histone H2A (Lys9) Rabbit mAb

5

Anti-Acetyl-Histone H2A (Lys9) Mouse mAb detects histone H2A only when it is acetylated at Lys9.

ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation

WB, IP, ChIP

Antibody

Research Use Only

Monoclonal

34H4L2

Unconjugated

Rabbit

IgG

Histone H2A type 1-B/E

Histone post-translational modifications (PTMs) are key mechanisms of epigenetics that modulate chromatin structures, termed as “histone code”. The PTMs on histone including acetylation, methylation, Phosphorylatedrylation and novel acylations directly affect the accessibility of chromatin to transcription factors and other epigenetic regulators, altering genome stability, gene transcription, etc. Histone acetylation occurs primarily at multiple lysine residues on the amino-terminal of core histones, in response to various stimuli and plays vital roles in the regulation of gene expression, DNA damage repair, chromatin dynamics, etc. Mostly, histone H2A is primarily acetylated at Lys5, 9, 15, and 36; H2B is primarily acetylated at Lys5, 12, 15, 16, and 20. Histone H3 is primarily acetylated at Lys4, 9, 14, 18, 23, 27, 56, and 79. Histone H4 is primarily acetylated at Lys5, 8, 12, 16, and 20. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) are major regulating factors

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse

Human, Mouse

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203