Anti-Acetyl-p53 (Lys139) Mouse mAb

PTM BIO

Anti-Acetyl-p53 (Lys139) Mouse mAb

5

Western Blot

WB

Antibody

Research Use Only

Monoclonal

Unconjugated

Mouse

IgG

Cellular tumor antigen p53

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. Acetylation of p53 is mediated by p300 and CBP acetyltransferases. Inhibition of deacetylation suppressing MDM2 from recruiting HDAC1 complex by p19 (ARF) stabilizes p53. Acetylation appears to play a positive role in the accumulation of p53 protein in stress response. Following DNA damage, human p53 becomes acetylated at Lys139 in vivo. The acetylation of p53 at lys139 site plays an important role in inhibiting mTOR pathway.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein G and immunogen affinity purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203