Anti-acetylcholine receptor [mAb198]

Absolute Antibody

Anti-acetylcholine receptor [mAb198]

7

This antibody is specific for the main immunogenic region of human acetylcholine receptor, which encompasses residues 67-76 of the extracellular region of the acetylcholine receptor alpha subunit. It cross-reacts with acetylcholine receptors from mammalia

The specificity of this antibody for the major immunogenic region of human acetylcholine receptor has been confirmed in Western blot and ELISA analysis (Barchan et al, 1998). This antibody cross-links acetylcholine receptors on the muscle surface and promotes their degradation; incubation of AChR-expressing cell lines with mAb198 results in a reduction in AChR (Barchan et al, 1988). Indeed, administration of this antibody to mice is sufficient to induce experimental autoimmune myasthenia gravis (EAMG), a neuromuscular disorder arising from a reduction in available acetylcholine receptors at the NMJ (Asher, 1993).

ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry, Other Application

Crystallisation; WB; ELISA; IP; IHC; deplete

Research Use Only

Monoclonal

mAb198

CHRNA1

cholinergic receptor nicotinic alpha 1 subunit

acetylcholine receptor subunit alpha; acetylcholine receptor, nicotinic, alpha 1 (muscle); ACHRA; ACHRD; cholinergic receptor, nicotinic alpha 1; cholinergic receptor, nicotinic, alpha 1 (muscle); cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle); CHRNA; CMS1A; CMS1B; CMS2A; FCCMS; muscle nicotinic acetylcholine receptor; nicotinic acetylcholine receptor alpha subunit; nicotinic cholinergic receptor alpha 1; SCCMS

Human

IgG1

Acetylcholine receptor subunit alpha

This chimeric human antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

This antibody was raised by immunising rats with acetylcholine receptor derived from human skeletal muscle.

-20°C,2°C to 8°C

12352203