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Anti-Acetyllysine Antibody Conjugated Agarose Beads

PTM-104
PTM BIO
ReactivityAll Species
Product group Antibodies
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Overview

  • Supplier
    PTM BIO
  • Product Name
    Anti-Acetyllysine Antibody Conjugated Agarose Beads
  • Delivery Days Customer
    5
  • Antibody Specificity
    With a mixture of high-quality rabbit- and mouse-derived anti-acetyllysine antibodies cross-linked, this Anti-Acetyllysine Antibody Conjugated Agarose Beads present extraordinary capability to specifically capture peptides/proteins bearing acetyllysine residues but do not cross-react with the peptides/proteins bearing structurally similar propionyllysine or butyryllysine residues. This product has been well utilized to affinity purify peptides for global proteomic screening of lysine acetylation.
  • Applications Supplier
    IAP
  • Category Supplier
    Antibody
  • Certification
    Research Use Only
  • Clonality
    Mix
  • Conjugate
    Agarose
  • Isotype
    IgG
  • Scientific Description
    The reversible lysine acetylation of histones and non-histone proteins plays a vital role in the regulation of many cellular processes including chromatin dynamics and gene activities, cell cycle progression, apoptosis, differentiation, DNA replication, DNA repair, nuclear import, and neuronal repression. The affinity purification with Anti-Acetyllysine Antibody Conjugated Agarose Beads followed by MS/MS identification is viewed as the most preferable and efficient method for systematical screening of lysine acetylated proteins.
  • Shelf life instruction
    Stable for 12 months from date of receipt.
  • Reactivity
    All Species
  • Reactivity Supplier
    All
  • Storage Instruction
    Store at -20°C. Avoid freeze/thaw cycles.
  • UNSPSC
    12352203

References

  • Meng Wu, et al. 'Promotion of Lung Cancer Metastasis by SIRT2-Mediated Extracellular Protein Deacetylation' Advanced Science (2022)
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  • Zhexu Chi, et al. 'Histone Deacetylase 3 Couples Mitochondria to Drive IL-1bèta-Dependent Inflammation by Configuring Fatty Acid Oxidation' MOLECULAR CELL (2020)
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  • Gaëlle Laurent, et al. 'SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase' MOLECULAR CELL (2013)
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  • Dong Hanyang, et al. 'TmcA functions as a lysine 2-hydroxyisobutyryltransferase to regulate transcription' Nature Chemical Biology (2021)
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  • Yue Sun, et al. 'Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death' Redox Biology (2022)
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  • Xiaoqiang Chai, et al. 'Quantitative acetylome analysis reveals histone modifications that may predict prognosis in hepatitis B-related hepatocellular carcinoma' Clinical and Translational Medicine (2021)
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  • Zongpan Jing, et al. 'Acetylation-induced PCK isoenzyme transition promotes metabolic adaption of liver cancer to systemic therapy' CANCER LETTERS (2021)
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  • WenChao Gao, et al. 'Targeting oxidative pentose phosphate pathway prevents recurrence in mutant Kras colorectal carcinomas' PLOS BIOLOGY (2019)
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  • Yanni Yin, et al. 'The ATP-binding protein FgArb1 is essential for penetration, infectious and normal growth of Fusarium graminearum' NEW PHYTOLOGIST (2018)
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  • Yue Chen, et al. 'Quantitative Acetylome Analysis Reveals the Roles of SIRT1 in Regulating Diverse Substrates and Cellular Pathways *' MOLECULAR & CELLULAR PROTEOMICS (2012)
    Read more