Anti-Acetyllysine Antibody Conjugated Agarose Beads
PTM-104
ReactivityAll Species
Product group Antibodies
Overview
- SupplierPTM BIO
- Product NameAnti-Acetyllysine Antibody Conjugated Agarose Beads
- Delivery Days Customer5
- Antibody SpecificityWith a mixture of high-quality rabbit- and mouse-derived anti-acetyllysine antibodies cross-linked, this Anti-Acetyllysine Antibody Conjugated Agarose Beads present extraordinary capability to specifically capture peptides/proteins bearing acetyllysine residues but do not cross-react with the peptides/proteins bearing structurally similar propionyllysine or butyryllysine residues. This product has been well utilized to affinity purify peptides for global proteomic screening of lysine acetylation.
- Applications SupplierIAP
- Category SupplierAntibody
- CertificationResearch Use Only
- ClonalityMix
- ConjugateAgarose
- IsotypeIgG
- Scientific DescriptionThe reversible lysine acetylation of histones and non-histone proteins plays a vital role in the regulation of many cellular processes including chromatin dynamics and gene activities, cell cycle progression, apoptosis, differentiation, DNA replication, DNA repair, nuclear import, and neuronal repression. The affinity purification with Anti-Acetyllysine Antibody Conjugated Agarose Beads followed by MS/MS identification is viewed as the most preferable and efficient method for systematical screening of lysine acetylated proteins.
- Shelf life instructionStable for 12 months from date of receipt.
- ReactivityAll Species
- Reactivity SupplierAll
- Storage InstructionStore at -20°C. Avoid freeze/thaw cycles.
- UNSPSC12352203
References
- Meng Wu, et al. 'Promotion of Lung Cancer Metastasis by SIRT2-Mediated Extracellular Protein Deacetylation' Advanced Science (2022)Read more
- Zhexu Chi, et al. 'Histone Deacetylase 3 Couples Mitochondria to Drive IL-1bèta-Dependent Inflammation by Configuring Fatty Acid Oxidation' MOLECULAR CELL (2020)Read more
- Gaëlle Laurent, et al. 'SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase' MOLECULAR CELL (2013)Read more
- Dong Hanyang, et al. 'TmcA functions as a lysine 2-hydroxyisobutyryltransferase to regulate transcription' Nature Chemical Biology (2021)Read more
- Yue Sun, et al. 'Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death' Redox Biology (2022)Read more
- Xiaoqiang Chai, et al. 'Quantitative acetylome analysis reveals histone modifications that may predict prognosis in hepatitis B-related hepatocellular carcinoma' Clinical and Translational Medicine (2021)Read more
- Zongpan Jing, et al. 'Acetylation-induced PCK isoenzyme transition promotes metabolic adaption of liver cancer to systemic therapy' CANCER LETTERS (2021)Read more
- WenChao Gao, et al. 'Targeting oxidative pentose phosphate pathway prevents recurrence in mutant Kras colorectal carcinomas' PLOS BIOLOGY (2019)Read more
- Yanni Yin, et al. 'The ATP-binding protein FgArb1 is essential for penetration, infectious and normal growth of Fusarium graminearum' NEW PHYTOLOGIST (2018)Read more
- Yue Chen, et al. 'Quantitative Acetylome Analysis Reveals the Roles of SIRT1 in Regulating Diverse Substrates and Cellular Pathways *' MOLECULAR & CELLULAR PROTEOMICS (2012)Read more