anti-ACVR2B / Activin Receptor Type IIB antibody

Arigo Biolaboratories

anti-ACVR2B / Activin Receptor Type IIB antibody

23

Western Blot

Research Use Only

Polyclonal

Unconjugated

ACVR2B

activin A receptor type 2B

activin A receptor, type IIB; activin receptor type-2B; ACTRIIB; ActR-IIB; HTX4

Rabbit

IgG

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]

Human

-20°C

12352203