Anti-ADAMts13 [1-420 scFv]

Absolute Antibody

Anti-ADAMts13 [1-420 scFv]

9

Mice transfected with the scFv show ADAMTS13 inhibition and accumulation of unprocessed UL-VWF (ultralarge VWF) multimers. 1-420 mediates inhibition by binding to the same spacer domain loop domain segments required for ADAMTS13 binding to VWF. Please note that this antibody is subject to a pending patent application by the The Trustees Of The University Of Pennsylvania (WO2016164468 A2).

Neutralisation/Blocking

Research Use Only

Monoclonal

1-420 scFv

Adamts13

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13

A disintegrin and metalloproteinase with thrombospondin motifs 13; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13; ADAM-TS13; ADAMTS-13; Gm710; von Willebrand factor-cleaving protease; vWF-cleaving protease; vWF-CP; vWF-CP mRNA for von Willebrand factor-cleaving

Human

IgG1

A disintegrin and metalloproteinase with thrombospondin motifs 13

This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203