Anti-Androgen Receptor

Applied Biological Materials

Anti-Androgen Receptor

9

Androgen Receptor antibody detects endogenous levels of Androgen Receptor protein. Not tested with other proteins

Western Blot, ELISA

Research Use Only

Polyclonal

Rabbit

IgG

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Human, Mouse

-20°C,2°C to 8°C

12352203