Anti-Angiogenin [26-2F]

Absolute Antibody

Anti-Angiogenin [26-2F]

9

Binds to human angiogenin with a Kd of 1.6 nM. Minimal epitope is W89 and fragment 38-41 (PCKD).

The antibody binds specifically to angiogenin, a member of of the ribonuclease superfamily of proteins, which interacts with actin on the surface of endothelial and smooth muscle cells, inducing neovascularization. Due to its angiogenic activity, angiogenesis plays a key role in the growth and invasiveness of tumour cells, and therefore neutralising monoclonal antibodies such as 26-2F are important anticancer drugs. The monoclonal antibody 26-2F is not directly cytotoxic to tumour cells in vitro, however has been shown to have antagonistic effects in human breast cancer xenografts in athymic mice.

ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, Neutralisation/Blocking

Research Use Only

Monoclonal

26-2F

ANG

angiogenin

ALS9; angiogenin; angiogenin, ribonuclease, RNase A family, 5; epididymis luminal protein 168; HEL168; RAA1; ribonuclease 5; ribonuclease A A1; ribonuclease A family member 5; RNase 5; RNASE4; RNASE5

Rabbit

IgG

Angiogenin

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human, Rabbit

-20°C,2°C to 8°C

12352203