Anti-Apaf1

Applied Biological Materials

Anti-Apaf1

9

Human

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Rabbit

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Human

-20°C,2°C to 8°C

12352203