Anti-Apo E [2E8]

Absolute Antibody

Anti-Apo E [2E8]

9

This antibody binds the LDL binding site RLASHLRKLRKRLLR of the human apolipoprotein E. This antibody binds well with apoE3 and poorly with apoE2. Apolipoprotein E (apoE), a 299 amino acid lipoprotein, is a ligand for the low density lipoprotein receptor

This antibody was reported to binds to apoE and blocks apoE-mediated binding of lipoproteins to the low density lipoprotein receptor (LDLr). It was also reported that this antibody resembles LDLr in showing reduced reactivity against apoE (Arg158Cys). The reactivity of this antibody to various apoE variants was determined using ELISA (PMID: 8558079). This antibody partially blocked the binding of apoE isoforms to the immobilized VLDL receptor (PMID: 15863833).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

2E8

APOE

apolipoprotein E

AD2; APO-E; ApoE4; apolipoprotein E; apolipoprotein E3; LDLCQ5; LPG

Human

IgG1

Apolipoprotein E

Human

-20°C,2°C to 8°C

12352203