anti-APRIL, mAb (Heaty-1)

AdipoGen Life Sciences

anti-APRIL, mAb (Heaty-1)

10

Recognizes mouse and human recombinant and endogenous APRIL.

ImmunoPrecipitation, ELISA

Research Use Only

Monoclonal

Heaty-1

1 mg/ml

>95%

Tnfsf13

tumor necrosis factor (ligand) superfamily, member 13

2310026N09Rik; a proliferation-inducing ligand; April; TA; Tall2; Tnlg7b; TRD; Trdl1; tumor necrosis factor ligand 7b; tumor necrosis factor ligand superfamily member 13

Mouse

IgG2b

Tumor necrosis factor ligand superfamily member 13

APRIL is a secreted cytokine, belonging to the TNF superfamily that binds to transmembrane activator and CAML interactor (TACI), B cell maturation antigen (BCMA) and can interact with carbohydrate side chains of heparan sulfate proteoglycans (HSPG) that may trigger cross-linking. APRIL maintains B cell homeostasis by acting at a later stage, modulating the function and survival of antigen-experienced B cells. APRIL (as well as BAFF) stimulates class-switch recombination (CSR), hence contributes to shaping humoral effector mechanisms. With regards to humoral memory, APRIL is involved in the establishment and survival of the long-lived plasma cell (LLPC) pool in the bone marrow (BM). Recently, APRIL has been shown to confer atheroprotection via binding to heparan sulfate (HS) chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits LDL retention,macrophage accumulation and necrotic core formation. - Monoclonal Antibody. Recognizes mouse and human recombinant and endogenous APRIL. Isotype: Mouse IgG2b. Immunogen: Recombinant mouse APRIL. Applications: ELISA, IP. Liquid. In PBS containing 0.02% Proclin 300. APRIL is a secreted cytokine, belonging to the TNF superfamily that binds to transmembrane activator and CAML interactor (TACI), B cell maturation antigen (BCMA) and can interact with carbohydrate side chains of heparan sulfate proteoglycans (HSPG) that may trigger cross-linking. APRIL maintains B cell homeostasis by acting at a later stage, modulating the function and survival of antigen-experienced B cells. APRIL (as well as BAFF) stimulates class-switch recombination (CSR), hence contributes to shaping humoral effector mechanisms. With regards to humoral memory, APRIL is involved in the establishment and survival of the long-lived plasma cell (LLPC) pool in the bone marrow (BM). Recently, APRIL has been shown to confer atheroprotection via binding to heparan sulfate (HS) chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits LDL retention,macrophage accumulation and necrotic core formation.

Human, Mouse

-20°C,2°C to 8°C

12352203