anti-Aquaporin 2 phospho (Ser 269) antibody

Arigo Biolaboratories

anti-Aquaporin 2 phospho (Ser 269) antibody

23

Western Blot, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

Aqp2

aquaporin 2

ADH water channel; AQP-2; AQP-CD; aquaporin 2 (collecting duct); aquaporin-2; aquaporin-CD; collecting duct water channel protein; water channel protein for renal collecting duct; WCH-CD

Rabbit

IgG

Phosphorylated

Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans (Iolascon et al., 2007). A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells (van Balkom et al., 2002). Serine-269 has been recently identified as a vasopressinmediated phosphorylation site on AQP2 and as such has shown to potentiate plasma membrane retention of AQP2 (Hoffert JD et al., 2008).

Bovine, Canine, Mouse, Rat

-20°C

12352203