Anti-ATM Rabbit mAb

PTM BIO

Anti-ATM Rabbit mAb

5

ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin

IHC-P, ICC/IF

Antibody

Research Use Only

Monoclonal

JRMR-231

Unconjugated

Rabbit

IgG

Serine-protein kinase ATM

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylatedrylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203