Anti-B7-H6 [17B1.3]

Absolute Antibody

Anti-B7-H6 [17B1.3]

9

mAb 17B1.3 specifically recognises B7-H6. 17B1.3 reacted with human tumour cell lines constitutively expressing B7-H6 such as HeLa cells. Fab 17B1.3 does not interfere with the binding of B7-H6 to NKp30, but nevertheless blocks NK cell activation.

B7-H6 is not detected in normal human tissues at steady state but is expressed on tumour cells, so tumour cells can be detected by NK cells. This article describes the study of the mechanisms that govern the induction of B7-H6 on primary cells as well as its consequences in vitro and in vivo.

Flow Cytometry, ImmunoFluorescence, Other Application

Research Use Only

Monoclonal

17B1.3

NCR3LG1

natural killer cell cytotoxicity receptor 3 ligand 1

B7 homolog 6; B7H6; B7-H6; DKFZp686O24166; natural cytotoxicity triggering receptor 3 ligand 1; putative Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167

Mouse

IgG1

Natural cytotoxicity triggering receptor 3 ligand 1

Human

-20°C,2°C to 8°C

12352203