Anti-Basigin [Ab-1]

Absolute Antibody

Anti-Basigin [Ab-1]

7

The antibody binds to basigin with an affinity (Kd) of 4 nM reported for the original antibody.

The antibody binds specifically to basigin, a protein of the immunoglobulin superfamily which is expressed on the surface of erythrocyte and acts as a receptor for the human malaria parasite P. falciparum. The recombinant chimeric monoclonal antibody Ab-1 acts by blocking the interaction between basigin and PfRH5, a ligand necessary for the P. falciparum erythrocyte invasion, thereby inhibiting the development of malaria.

ELISA, Neutralisation/Blocking

ELISA; Block

Research Use Only

Monoclonal

Ab-1

BSG

basigin (Ok blood group)

5F7; basigin; CD147; collagenase stimulatory factor; EMMPRIN; EMPRIN; extracellular matrix metalloproteinase inducer; HAb18G; hepatoma-associated antigen; leukocyte activation antigen M6; OK; OK blood group antigen; SLC7A11; TCSF; tumor cell-derived collagenase stimulatory factor

Human

IgG1

Basigin

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

Recombinant ectodomains of human basigin.

-20°C,2°C to 8°C

12352203