Anti-BAX [3C10]

Absolute Antibody

Anti-BAX [3C10]

9

The antibody is specific for Bax. It recognizes a peptide encompassing residues 31-45 at the start of Bax a1-a2 loop (AAs RAGRM).

The specificity of the antibody for Bax was determined by ELISA analysis. The antibody was able to bind to mitochondrial Bax and WT Bax by western blot analysis. The antibody immunoprecipitated Bax (Iyer et al., 2016; PMID: 27217060). The crystal structure of the Fab fragment in complex with BAX was determined. The antibody activates mitochondrial Bax, but blocks translocation of cytosolic Bax (Robin et al., 2018; PMID: 30122452).

ImmunoPrecipitation, Western Blot, ELISA, Other Application

Research Use Only

Monoclonal

3C10

BAX

BCL2 associated X, apoptosis regulator

apoptosis regulator BAX; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; BCL2 associated X protein; BCL2-associated X protein omega; BCL2L4; bcl2-L-4; bcl-2-like protein 4

Rabbit

IgG

Apoptosis regulator BAX

Human

-20°C,2°C to 8°C

12352203