Anti-Bcr (Phospho-Tyr177)

Applied Biological Materials

Anti-Bcr (Phospho-Tyr177)

9

Bcr (phospho-Tyr177) antibody detects endogenous levels of Bcr only when phosphorylated at tyrosine 177.

Western Blot, ImmunoHistoChemistry

Research Use Only

Polyclonal

1 ug/ul

Rabbit

Phosphorylated

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Human, Mouse

-20°C,2°C to 8°C

12352203