Anti-Bet v 1 [H3-1]

Absolute Antibody

Anti-Bet v 1 [H3-1]

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This antibody reacts with native Bet v 1 and homologous allergens. This antibody can also bind Bet v 1-related allergens namely Aln g 1, Cor a 1, Mal d 1. This antibody specifically binds C-terminal F2 domain of Bet v 1 (amino acids 130-160) and the bindi

The reactivity of this antibody to Bet v 1 and related allergens Aln g 1, Cor a 1, Mal d 1 was determined using ELISA. This antibody reacted best with rBet v 1 but also with the cross-reactive allergens from alder (Aln g 1), hazel (Cor a 1), and apple (Mal d 1). The original scFv version of this antibody binds Bet v 1, Aln g 1, Cor a 1, and Mal d 1 with a binding affinity of Bet v 1: KD= 6.22 x 10-10 M, Mal d 1: KD= 2.57 x 10-9 M, Aln g 1: KD= 2.96 x 10-9 M and Cor a 1: KD= 6.83 x 10-9 M respectively (PMID: 29315611). This antibody inhibited allergic patients polyclonal IgE binding to Bet v 1, and partially suppressed allergen-induced basophil activation (PMID: 29315611).

ELISA

Research Use Only

Monoclonal

H3-1

Human

IgE

Major pollen allergen Bet v 1-A

This full-length reformatted human antibody was made using the variable domain sequences of the original Human scFv format for improved compatibility with existing reagents assays and techniques.

Plant

-20°C,2°C to 8°C

12352203