Anti-bèta-Hydroxybutyryl-Histone H3 (Lys9) Rabbit mAb

PTM BIO

Anti-bèta-Hydroxybutyryl-Histone H3 (Lys9) Rabbit mAb

5

Anti-bèta-Hydroxybutyryl-Histone H3 (Lys9) Rabbit mAb detects histone H3 only when it is bèta-hydroxybutyrylated at Lys9. This antibody has been shown to selectively recognize bèta-hydroxybutyrylated H3 peptide at Lys9, but not the acetylated, crotonylated, butyrylated, 2-hydroxyisobutyrylated, or unmodified H3 peptide at Lys9 or Lys27.

Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P

Antibody

Research Use Only

Monoclonal

PA-022-8

Unconjugated

Rabbit

IgG

Histone H3.1

Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitination, and numerous others. bèta-Hydroxybutyrylation of lysine (Kbhb) is a newly identified histone marker that is enriched in active gene promoters. Histone Kbhb marks are dramatically induced in response to elevated bèta-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prolonged fasting or streptozotocin-induced diabetic ketoacidosis. Histone bèta-hydroxybutyrylation represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of bèta-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia.

Stable for 12 months from date of receipt/reconstitution.

Human, Rat

Human, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203