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ProductsBack/Anti-bèta-Hydroxybutyryl-Histone H4 (Lys12) Rabbit mAb

Anti-bèta-Hydroxybutyryl-Histone H4 (Lys12) Rabbit mAb

PTM-1206RM
PTM BIO
ApplicationsImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
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Overview

  • Supplier
    PTM BIO
  • Product Name
    Anti-bèta-Hydroxybutyryl-Histone H4 (Lys12) Rabbit mAb
  • Delivery Days Customer
    5
  • Antibody Specificity
    Anti-bèta-Hydroxybutyryl-Histone H4 (Lys12) Rabbit mAb detects histone H4 only when it is bèta-hydroxybutyrylated at Lys12.
  • Applications
    ImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry
  • Applications Supplier
    WB, ICC/IF, ChIP
  • Category Supplier
    Antibody
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    9H1L2
  • Conjugate
    Unconjugated
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP62805
  • Protein Name
    Histone H4
  • Scientific Description
    Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitination, etc. bèta-Hydroxybutyrylation of lysine (Kbhb) is a newly identified histone marker that is enriched in active gene promoters. Histone Kbhb marks are dramatically induced in response to elevated bèta-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prolonged fasting or streptozotocin-induced diabetic ketoacidosis. Histone bèta-hydroxybutyrylation represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of bèta-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia.
  • Shelf life instruction
    Stable for 12 months from date of receipt/reconstitution.
  • Reactivity
    Human
  • Reactivity Supplier
    Human
  • Reactivity Supplier Note
    Protein A purified
  • Storage Instruction
    Store at -20°C. Avoid freeze/thaw cycles.
  • UNSPSC
    12352203

References

  • Yufan Zheng, et al. 'bèta-hydroxybutyrate inhibits ferroptosis-mediated pancreatic damage in acute liver failure through the increase of H3K9bhb' Cell Reports (2022)
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