Anti-bèta-Hydroxybutyryllysine Antibody Conjugated Agarose Beads

PTM BIO

Anti-bèta-Hydroxybutyryllysine Antibody Conjugated Agarose Beads

5

With the immobilization of highly specific anti-bèta-hydroxybutyryllysine antibodies, the Anti-bèta-Hydroxybutyryllysine Antibody Conjugated Agarose Beads selectively capture peptides/proteins bearing bèta-hydroxybutyryllysine residues, but do not cross-react with the peptides/proteins bearing other structurally similar modified residues. This product has been well utilized to affinity purify peptides for global proteomic screening of lysine bèta-hydroxybutyrylation.

IAP

Antibody

Research Use Only

Mix

Agarose

IgG

Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitination, etc. bèta-Hydroxybutyrylation of lysine (Kbhb) is a newly identified histone marker that is enriched in active gene promoters. Histone Kbhb marks are dramatically induced in response to elevated bèta-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prolonged fasting or streptozotocin-induced diabetic ketoacidosis. Histone bèta-hydroxybutyrylation represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of bèta-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia.

Stable for 12 months from date of receipt.

All Species

All

Store at -20°C. Avoid freeze/thaw cycles.

12352203