Anti-bèta-Hydroxybutyryllysine Rabbit mAb

PTM BIO

Anti-bèta-Hydroxybutyryllysine Rabbit mAb

5

Anti-bèta-Hydroxybutyllysine Rabbit mAb detects proteins post-translationally modified by bèta-hydroxybutylation on lysine residues. This pan antibody recognizes bèta-hydroxybutylated lysine independent of its surrounding sequences.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin

WB, IHC-P, ICC/IF

Antibody

Research Use Only

Monoclonal

7H1L3

Unconjugated

Rabbit

IgG

Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitination, etc. bèta-Hydroxybutyrylation of lysine (Kbhb) is a newly identified histone marker that is enriched in active gene promoters. Histone Kbhb marks are dramatically induced in response to elevated bèta-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prolonged fasting or streptozotocin-induced diabetic ketoacidosis. Histone bèta-hydroxybutyrylation represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of bèta-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia.

Stable for 12 months from date of receipt/reconstitution.

All Species

All

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203