Anti-Beta Lactamase [cAbTEM13]

Absolute Antibody

Anti-Beta Lactamase [cAbTEM13]

9

This antibody binds an enzyme called beta-lactamase produced by bacteria, which catalysis the breaking of the beta-lactam ring of beta-lactam antibiotics such as penicillin, cephalosporin, cephamycin and monobactam through hydrolysis. The breaking of the

The binding reactivity of this antibody to TEM-1 beta-lactamase was determined using ELISA. This antibody was capable of inhibiting beta-lactamase activity in vitro with an IC50 of 0.08 microM. The in vivo inhibition activity of this antibody to inhibit surface-exposed TEM-1 and prevent bacterial growth was assessed by preincubating cells expressing TEM-1 with increasing amounts of the antibody fragment. It was reported that when cells were preincubated with cAbTem13 before plating lost their ability to neutralize the antibiotic ampicillin (PMID: 11557473).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

cAbTEM13

blaTEM-1

TEM-1 beta-lactamase

p3521_p066; TEM-1 beta-lactamase

Rabbit

IgG

Beta-lactamase TEM

Bacteria

-20°C,2°C to 8°C

12352203