anti-BIM antibody

Arigo Biolaboratories

anti-BIM antibody

23

Western Blot

Research Use Only

Polyclonal

0.5 mg/ml

Unconjugated

BCL2L11

BCL2 like 11

BAM; bcl-2 interacting mediator of cell death; bcl-2 interacting protein Bim; BCL2-like 11 (apoptosis facilitator); bcl-2-like protein 11; bcl-2-related ovarian death agonist; BIM; BOD

Goat

IgG

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jul 2008]

Human

-20°C

12352203