Anti-BLC2 [bcl-2/124]

Absolute Antibody

Anti-BLC2 [bcl-2/124]

9

This antibody recognises human BLC-2 which is an antiapoptotic factor in various cell types. Its disregulation was implicated in different conditions, such as cancers and autoimmune disorders.

This antibody has been used extensively in attempts aimed at characterising various cancer tissues via immunohistochemical staining. One group used bcl-2-124 antibody to label large B-cell lymphoma samples for bcl2 in order to perform its immunophenotypic and genetic depiction (Chang et al., 2016). Another group took advantage of this antibody while analysing the molecular picture of a case of the cystic synovial sarcoma of the pleura where they observed positive immunohistochemical staining in tumor cells (Tajima et al., 2015). Bcl-2 plays an important role as an inhibitor of apoptosis and its identification is often useful while analysing various factors influencing apoptosis. For instance, bcl-2/124 antibody has been successfully utilised in such experiments identifying bcl-2 via Western blot - Gomez-Bougie (2007) probed the influence of bortezomib on HMCL cells and detected bcl-2 signal on Western blots.

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

bcl-2/124

BCL2

BCL2 apoptosis regulator

apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; Bcl-2; PPP1R50; protein phosphatase 1, regulatory subunit 50

Rabbit

IgG

Apoptosis regulator Bcl-2

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203