Anti-Bovine coronavirus [SF-3E4]

Absolute Antibody

Anti-Bovine coronavirus [SF-3E4]

9

This antibody recognises an epitope in the S1 subunit of the BCV spike protein.

An scFv version of this antibody exhibits good binding kinetics (Km = 595 pM) and neutralization ability (≥ 0.24 microg/ml) against BCV-V270 in ELISA analysis and neutralisation assays using BCV-V270-infected VERO cell cultures (Fischer, 2017). Western blotting and a competition ELISA with BCV-V270 have shown that this scFv recognises an epitope in the BCV spike protein (Fischer, 2017). In ELISA analysis, this scFv cross-reacts with BCV-L9 and the human coronavirus strain OC43 (Fischer, 2017). This scFv is a potential therapeutic candidate for the treatment of calf diarrhea caused by coronaviruses.

Western Blot, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

SF-3E4

Rabbit

IgG

This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original scFv format, for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203