anti-Bub3 phospho (Tyr207) antibody

Arigo Biolaboratories

anti-Bub3 phospho (Tyr207) antibody

23

Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

BUB3

BUB3 mitotic checkpoint protein

BUB3 budding uninhibited by benzimidazoles 3 homolog; BUB3L; budding uninhibited by benomyl; budding uninhibited by benzimidazoles 3 homolog; hBUB3; mitotic checkpoint component; mitotic checkpoint protein BUB3; testicular tissue protein Li 27

Rabbit

IgG

Phosphorylated

Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.

Human

-20°C

12352203