Anti-Butyryl-Histone H2B (Lys20) Mouse mAb

PTM BIO

Anti-Butyryl-Histone H2B (Lys20) Mouse mAb

5

Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P

Antibody

Research Use Only

Monoclonal

Unconjugated

Mouse

IgG

Histone H2B type 1-C/E/F/G/I

Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitylation, etc. Butyrylation of lysine, structurally similar to lysine acetylation, is a newly identified reversible modification controlling protein activity. The reversible lysine butyrylation has been well demonstrated in both prokaryotes and eukaryotes in wide ranges of proteins including histones and non-histone substrates, such as p53. Similar to acetylation of histione H4 at lysine 12, butyrylation of histone H2B at lysine 20 may play a vital role in the epigenetic modulation, including chromatin remodeling, and DNA transcriptional regulation.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein G and immunogen affinity purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203