Anti-Butyryl-Histone H2B (Lys23) Rabbit mAb

PTM BIO

Anti-Butyryl-Histone H2B (Lys23) Rabbit mAb

5

Anti-Butyryl-Histone H2B (Lys23) Rabbit mAb detects histone H2B only when it is butyrylated at Lys23.

Western Blot, ChIP Chromatin ImmunoPrecipitation

WB, ChIP

Antibody

Research Use Only

Monoclonal

PD-154-27

Unconjugated

Rabbit

IgG

Histone H2B type 1-C/E/F/G/I

Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitylation, etc. Butyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. Lysine butyrylation is highly conserved in eukaryotic cells from worm to human. The unique structure and genomic localization of histone lysine butyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and rabbit male germ cell genomes, histone butyrylation marks either active promoters or potential enhancers. Butyrylation of histone H3 at Lys23 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203