ProductsBack/Anti-Butyryl-Histone H3 (Lys18) Mouse mAb

Anti-Butyryl-Histone H3 (Lys18) Mouse mAb

Name: Anti-Butyryl-Histone H3 (Lys18) Mouse mAb
SKU: PTM-331_P78
Availability: BackOrder

PTM-331

ApplicationsWestern Blot, ChIP Chromatin ImmunoPrecipitation

Product group Antibodies

ReactivityHuman, Mouse, Rat

Overview

Supplier
PTM BIO
Product Name
Anti-Butyryl-Histone H3 (Lys18) Mouse mAb
Delivery Days Customer
5
Applications
Western Blot, ChIP Chromatin ImmunoPrecipitation
Applications Supplier
WB, ChIP
Category Supplier
Antibody
Certification
Research Use Only
Clonality
Monoclonal
Conjugate
Unconjugated
Host
Mouse
Isotype
IgG
Protein IDP68431
Protein Name
Histone H3.1
Scientific Description
Histones are subjected to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitylation, etc. Butyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. Lysine butyrylation is highly conserved in eukaryotic cells from worm to human. The unique structure and genomic localization of histone lysine butyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and rabbit male germ cell genomes, histone butyrylation marks either active promoters or potential enhancers. Butyrylation of histone H3 at Lys18 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.
Shelf life instruction
Stable for 12 months from date of receipt/reconstitution.
Reactivity
Human, Mouse, Rat
Reactivity Supplier
Human, Mouse, Rat
Reactivity Supplier Note
Protein G and immunogen affinity purified
Storage Instruction
Store at -20°C. Avoid freeze/thaw cycles.
UNSPSC
12352203

Zhi Yang, et al. 'Histone H3K9 butyrylation is regulated by dietary fat and stress via an Acyl-CoA dehydrogenase short chain-dependent mechanism' Molecular Metabolism (2021)
Read more