Anti-Butyryl-Histone H3 (Lys18) Rabbit mAb

PTM BIO

Anti-Butyryl-Histone H3 (Lys18) Rabbit mAb

5

Anti-Butyryl-Histone H3 (Lys18) Rabbit mAb detects histone H3 only when it is butyrylated at Lys18.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

WB, ICC/IF

Antibody

Research Use Only

Monoclonal

PA-177-23

Unconjugated

Rabbit

IgG

Histone H3.1

Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitylation, etc. Butyrylation of lysine, structurally similar to lysine acetylation and propionylation, is a newly identified reversible modification controlling chromosome structure and gene transcription. With integrated proteomic approaches and biochemistry analysis, lysine butyrylation has been well demonstrated in both prokaryotes and eukaryotes. The unique structure and genomic localization of histone lysine butyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Butyrylation of histone H3 at Lys18 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203