More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/Anti-Butyryl-Histone H3 (Lys23) Mouse mAb

Anti-Butyryl-Histone H3 (Lys23) Mouse mAb

PTM-307
PTM BIO
ApplicationsWestern Blot, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    PTM BIO
  • Product Name
    Anti-Butyryl-Histone H3 (Lys23) Mouse mAb
  • Delivery Days Customer
    5
  • Antibody Specificity
    Anti-Butyryl-Histone H3 (Lys23) Mouse mAb detects histone H3 only when it is butyrylated at Lys23.
  • Applications
    Western Blot, ImmunoHistoChemistry Paraffin
  • Applications Supplier
    WB, IHC-P
  • Category Supplier
    Antibody
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Conjugate
    Unconjugated
  • Host
    Mouse
  • Isotype
    IgG
  • Protein IDP68431
  • Protein Name
    Histone H3.1
  • Scientific Description
    Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitylation, etc. Butyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. Lysine butyrylation is highly conserved in eukaryotic cells from worm to human. The unique structure and genomic localization of histone lysine butyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and rabbit male germ cell genomes, histone butyrylation marks either active promoters or potential enhancers. Butyrylation of histone H3 at Lys18 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.
  • Shelf life instruction
    Stable for 12 months from date of receipt/reconstitution.
  • Reactivity
    Human, Mouse, Rat
  • Reactivity Supplier
    Human, Mouse, Rat
  • Reactivity Supplier Note
    Protein G and immunogen affinity purified
  • Storage Instruction
    Store at -20°C. Avoid freeze/thaw cycles.
  • UNSPSC
    12352203

References

  • Kezhi Yan, et al. 'Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer' Science Advances (2020)
    Read more
  • Aditya Bhattacharya, et al. 'Butyrylation Meets Adipogenesis-Probed by a p300-Catalyzed Acylation-Specific Small Molecule Inhibitor: Implication in Anti-obesity Therapy' JOURNAL OF MEDICINAL CHEMISTRY (2022)
    Read more
  • Jo Chanhee, et al. 'Histone acylation marks respond to metabolic perturbations and enable cellular adaptation' EXPERIMENTAL AND MOLECULAR MEDICINE (2020)
    Read more