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Anti-Butyryl-Histone H4 (Lys5) Mouse mAb

PTM-310
PTM BIO
ApplicationsWestern Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
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Overview

  • Supplier
    PTM BIO
  • Product Name
    Anti-Butyryl-Histone H4 (Lys5) Mouse mAb
  • Delivery Days Customer
    5
  • Antibody Specificity
    Anti-Butyryl-Histone H4 (Lys5) Mouse mAb detects histone H4 only when it is butyrylated at Lys5.
  • Applications
    Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoHistoChemistry Paraffin
  • Applications Supplier
    WB, IHC-P, ChIP
  • Category Supplier
    Antibody
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Conjugate
    Unconjugated
  • Host
    Mouse
  • Isotype
    IgG
  • Protein IDP62805
  • Protein Name
    Histone H4
  • Scientific Description
    Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitylation, etc. Butyrylation of lysine, structurally similar to lysine acetylation, is a newly identified reversible modification controlling protein activity. The reversible lysine butyrylation has been well demonstrated in both prokaryotes and eukaryotes in wide ranges of proteins including histones and non-histone substrates, such as p53. Similar to acetylation of histione H4 at lysine 12, butyrylation of histone H4 at lysine 5 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.
  • Shelf life instruction
    Stable for 12 months from date of receipt/reconstitution.
  • Reactivity
    Human, Mouse, Rat
  • Reactivity Supplier
    Human, Mouse, Rat
  • Reactivity Supplier Note
    Protein G and immunogen affinity purified
  • Storage Instruction
    Store at -20°C. Avoid freeze/thaw cycles.
  • UNSPSC
    12352203

References

  • Mengqing Gao, et al. 'Metabolically controlled histone H4K5 acylatiocetylation ratio drives BRD4 genomic distribution' Cell Reports (2021)
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  • Aditya Bhattacharya, et al. 'Butyrylation Meets Adipogenesis-Probed by a p300-Catalyzed Acylation-Specific Small Molecule Inhibitor: Implication in Anti-obesity Therapy' JOURNAL OF MEDICINAL CHEMISTRY (2022)
    Read more