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ProductsBack/Anti-Butyryl-Histone H4 (Lys8) Rabbit pAb

Anti-Butyryl-Histone H4 (Lys8) Rabbit pAb

PTM-311
PTM BIO
ApplicationsImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
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Overview

  • Supplier
    PTM BIO
  • Product Name
    Anti-Butyryl-Histone H4 (Lys8) Rabbit pAb
  • Delivery Days Customer
    5
  • Applications
    ImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry
  • Applications Supplier
    WB, ICC/IF, ChIP
  • Category Supplier
    Antibody
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP62805
  • Protein Name
    Histone H4
  • Scientific Description
    Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitylation, etc. Butyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. Lysine butyrylation is highly conserved in eukaryotic cells from worm to human. The unique structure and genomic localization of histone lysine butyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and rabbit male germ cell genomes, histone butyrylation marks either active promoters or potential enhancers. Butyrylation of histone H3 at Lys18 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.
  • Shelf life instruction
    Stable for 12 months from date of receipt/reconstitution.
  • Reactivity
    Human, Mouse, Rat
  • Reactivity Supplier
    Human, Mouse, Rat
  • Reactivity Supplier Note
    Protein A and immunogen affinity purified
  • Storage Instruction
    Store at -20°C. Avoid freeze/thaw cycles.
  • UNSPSC
    12352203

References

  • Afsaneh Goudarzi, et al. 'Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters' MOLECULAR CELL (2016)
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  • Mengqing Gao, et al. 'Metabolically controlled histone H4K5 acylatiocetylation ratio drives BRD4 genomic distribution' Cell Reports (2021)
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  • Aditya Bhattacharya, et al. 'Butyrylation Meets Adipogenesis-Probed by a p300-Catalyzed Acylation-Specific Small Molecule Inhibitor: Implication in Anti-obesity Therapy' JOURNAL OF MEDICINAL CHEMISTRY (2022)
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