Anti-Butyryllysine Rabbit mAb (BSA and Azide Free)

PTM BIO

Anti-Butyryllysine Rabbit mAb (BSA and Azide Free)

5

Anti-Butyryllysine Rabbit mAb (BSA and Azide Free) detects proteins with Butyrylated lysine residues. This pan antibody recognizes Butyrylated lysine independent of its surrounding sequences.

Western Blot

WB

Antibody

Research Use Only

Monoclonal

PSPTM-O0401

Unconjugated

Rabbit

IgG

Butyrylation of lysine, structurally similar to lysine acetylation and lysine propionylation, is a newly identified reversible modification controlling protein activity. With integrated proteomic approaches and biochemistry analysis, lysine butyrylation has been well demonstrated in both prokaryotes and eukaryotes in wide ranges of proteins including histones and non-histone substrates. Given the facts that many lysine residues in histones and non-histone substrates, such as p53, p300/CBP, are butyrylated, lysine butyrylation may play a vital role in epigenetic modulation by impacting on chromatin dynamics and plasticity, DNA transcriptional regulation and tumorigenesis, etc.

Stable for 12 months from date of receipt/reconstitution.

All Species

All

Protein A purified

Before reconstitution, centrifuge the vial at 12,000 x g for 20 seconds. Add 100 uL sterile, deionized water to achieve a final antibody concentration of 1 mg/ml. After reconstitution, the antibody will be in a 1X PBS solution. Aliquot and store at -80°C. Avoid freeze/thaw cycles.

12352203