Anti-Butyryllysine Rabbit mAb

PTM BIO

Anti-Butyryllysine Rabbit mAb

5

Anti-Butyryllysine Rabbit mAb detects proteins post-translationally modified by butyrylation on lysine residues. This pan antibody recognizes butyrylated lysine independent of its surrounding sequences.

ImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin

WB, IHC-P, ICC/IF, ChIP

Antibody

Research Use Only

Monoclonal

PSPTM-419-17

Unconjugated

Rabbit

IgG

Butyrylation of lysine, structurally similar to lysine acetylation and lysine propionylation, is a newly identified reversible modification controlling protein activity. With integrated proteomic approaches and biochemistry analysis, lysine butyrylation has been well demonstrated in both prokaryotes and eukaryotes in wide ranges of proteins including histones and non-histone substrates. Given the facts that many lysine residues in histones and non-histone substrates, such as p53, p300/CBP, are butyrylated, lysine butyrylation may play a vital role in epigenetic modulation by impacting on chromatin dynamics and plasticity, DNA transcriptional regulation and tumorigenesis, etc.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203