Anti-c-erbB-2 [FWP51]

Absolute Antibody

Anti-c-erbB-2 [FWP51]

7

Immunofluorescence and immunoprecipitation were used to confirm the specificity of FWP51 for c-erbB-2 (Harwerth et al, 1992). Flow cytometry showed that FWP51 binds the extracellular domain of c-erbB-2 (Harwerth et al, 1992). FWP51 has also been fused to the bacterial toxin, exotoxin A. The resultant fusion protein Fv(FWP51)-ETA selectively inhibited protein synthesis in cells expressing high levels of human c-erbB-2 protein, but not in cells expressing little to no human c-erbB-2 protein. Administration of FWP51 to mice impanted with human erbB-2 transformed NIH3T3 cells led to inhibition of the onset of tumour growth (Harwerth et al, 1993).

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation

IF; IP; FC; fusion

Research Use Only

Receptor tyrosine-protein kinase erbB-2

-20°C,2°C to 8°C

12352203