Anti-C3 [C3-2]

Absolute Antibody

Anti-C3 [C3-2]

9

The antibody interacts specifically with native C3, containing an intact thioester bond and not with an inactive form of C3, containing a hydrolysed ester bond. The epitope in part located on the 23kD-alpha-chain fragment of C3c.

The specificity of the original format of the antibody was confirmed by ELISA analysis. The binding affinity of the humanised version of the antibody to native C3 was measured by surface plasmon resonance (Kd= 5.9 nM). The murine and the humanised version of the antibody could inhibit the activation of C3 (WO2004031240A1).

Western Blot, ELISA, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

C3-2

C3

complement C3

acylation-stimulating protein cleavage product; AHUS5; ARMD9; ASP; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3a; C3a anaphylatoxin; C3b; complement C3; complement component 3; complement component C3a; complement component C3b; CPAMD1; epididymis secretory sperm binding protein Li 62p; HEL-S-62p; prepro-C3

Human

IgG1

Complement C3

Human

-20°C,2°C to 8°C

12352203