Anti-C5 [Eculizumab]

Absolute Antibody

Anti-C5 [Eculizumab]

7

Binds human C5 centred in the MG7 domain, at an epitope spanning Lys-879 to Arg-885 (Jore et al. 2016) Polymorphisms at Arg-885 correlate with drug resistance. Eculizumab demonstrates no appreciable species cross-reactivity. It is highly species specific.

This antibody inhibits activation of C5. The human Fab version (Ab00296-10.6) of this antibody was used by Jore et al. (2016, PMID: 27018802) to determine the binding site of this antibody to C5.

Electron Microscopy, ELISA, Neutralisation/Blocking

Block; EM; ELISA

Research Use Only

Monoclonal

Eculizumab

C5

complement C5

anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5a; C5a anaphylatoxin; C5b; C5D; complement C5; complement component 5; CPAMD4; ECLZB; prepro-C5

Rabbit

IgG

Complement C5

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG2/4 format, for improved compatibility with existing reagents, assays and techniques.

Human

Human

C5 is activated by C5 converatse into C5a, an anaphylatoxin, and C5b a component of the membrane attack complex.

-20°C,2°C to 8°C

12352203