Anti-C5a [Fab 102]

Absolute Antibody

Anti-C5a [Fab 102]

9

Fab 102 binds only to C5a and not to C5. This antibody is likely to recognise a conformational epitope because it failed to bind C5a when it was linked to microtiter plates. The epitope is outside the active site of C5a.

Fab 102 has been used in ELISAs in order to specifically detect C5a and quantify C5a in human CSF (Stahel 1997). It can be used to block C5a binding to its receptor. mAbs to C5a may have a therapeutic benefit in sepsis/ARDS.

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

Fab 102

C5

complement C5

anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5a; C5a anaphylatoxin; C5b; C5D; complement C5; complement component 5; CPAMD4; ECLZB; prepro-C5

Human

Complement C5

This chimeric human antibody was made using the variable domain sequences of the original Mouse Fab format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203