anti-Caspase 9 (cleaved) antibody

Arigo Biolaboratories

anti-Caspase 9 (cleaved) antibody

23

ImmunoPrecipitation, Western Blot

Research Use Only

Polyclonal

0.2 mg/ml

Unconjugated

CASP9

caspase 9

APAF3; APAF-3; apoptotic protease activating factor 3; apoptotic protease MCH-6; caspase 9, apoptosis-related cysteine peptidase; caspase-9; ICE-LAP6; ICE-like apoptotic protease 6; MCH6; PPP1R56; protein phosphatase 1, regulatory subunit 56

Rabbit

IgG

Caspases are synthesized as inactive pro-enzymes that are processed to active form in cells undergoing apoptosis. Caspase-9 is an important member of the caspase family. Upon induction of apoptosis, Cytochrome c released from mitochondria associates with pro-caspase-9 (47 kDa) and Apaf-1. The complex processes pro-caspase-9 into a large subunit (37 kDa/17 kDa) and a small subunit (10 kDa). Cleaved caspase-9 further processes other caspases including caspase-3 and caspase-6, to initiate a caspase cascade leading to apoptosis. The affinity purified antibody recognizing the active forms of caspase-9 provides a new tool for identifying apoptotic cell populations in both tissue sections and cultured cells.

Human

-20°C

12352203