anti-CCM2 antibody

Arigo Biolaboratories

anti-CCM2 antibody

23

Western Blot

Research Use Only

Polyclonal

0.5 mg/ml

Unconjugated

CCM2

CCM2 scaffold protein

C7orf22; CCM2 scaffolding protein; cerebral cavernous malformation 2; cerebral cavernous malformations 2 protein; malcavernin; OSM; osmosensing scaffold for MEKK3; PP10187

Goat

IgG

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]

Bovine, Canine, Human, Mouse, Rat

-20°C

12352203