Anti-CCR2 [MLN1202 (Plozalizumab, hu1D9)]

Absolute Antibody

Anti-CCR2 [MLN1202 (Plozalizumab, hu1D9)]

9

This antibody binds and epitope between amino acids 1-30 in the amino terminal region of human CC-chemokine receptor 2. CCR2 receptor is a key functional receptor for CCL2, a chemokine which specifically mediates monocyte chemotaxis. CCL2 is involved in m

The binding characterization of the original mouse parental antibody 1D9 for human CCR2 was done using flow cytometry. This humanized antibody was capable of inhibit the binding of [125I]-MCP-1 to whole THP-1 cells (US6696550). In a clinical trial study, in patients with active rheumatoid arthritis (RA), it was reported that treatment with anti-CCR2 blocking antibody did not result in amelioration of synovial inflammation in active RA (PMID: 18576354). In a study in patients with risk factors for atherosclerotic cardiovascular disease (ASCVD), it was reported that that blockade of CCR2 with MLN1202 reduces C-reactive protein, a biomarker related to inflammation in patients at risk for ASCVD (Davidson et. al., 2007). In another study, patients with ASCVD, who received MLN1202 exhibited significant decreases in high-sensitivity C-reactive protein levels, beginning at 4 weeks and continuing through 12 weeks after dosing (PMID: 21247529). A phase II clinical trial (NCT01015560) in patients with bone metastases resulting from unspecified solid tumors, reported that administration of MLN1202 was well tolerated in patients with < 8% reporting serious adverse events although only 14 patients (~32%) had a considerable reduction in urinary N-telopeptide values after 43 days of treatment (PMID: 26885690).

Flow Cytometry, Neutralisation/Blocking

Research Use Only

Monoclonal

MLN1202 (Plozalizumab, hu1D9)

CCR2

C-C motif chemokine receptor 2

C-C chemokine receptor type 2; CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; chemokine (C-C motif) receptor 2; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1 receptor; MCP-1-R; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor

Mouse

IgG2b

C-C chemokine receptor type 2

This is a reformatted mouse IgG2b Fc Silent™ antibody, based on the original mouse IgG1 format, created for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203