Anti-CCR5 [ST6]

Absolute Antibody

Anti-CCR5 [ST6]

9

This antibody is specific for the YTSE region of the N-terminal extracellular domain of human CCR5.It also binds to rhesus CCR5.

When expressed intracellularly, this antibody is able to inhibit the surface expression of human CCR5, conferring T-lymphocytes with immunity to CCR5-dependent HIV-1 infection (Steinberger et al, 2000). Humanised ST6 (ST6/34) also has the same depleting effect (Steinberger et al, 2000). The high affinity of this antibody for CCR5-N-MBP has been confirmed in surface plasmon resonance analysis (Steinberg et al, 2000). This antibody has been used to stain CCR5-expressing cells in flow cytometry, with no staining of control cells observed (Steinberger et al, 2000).

Flow Cytometry, ELISA, Other Application

Research Use Only

Monoclonal

ST6

CCR5

C-C motif chemokine receptor 5

C-C chemokine receptor type 5; C-C motif chemokine receptor 5 A159A; CCCKR5; CC-CKR-5; CCR-5; CD195; chemokine (C-C motif) receptor 5; chemokine receptor CCR5; chemokine recptor CCR5 Delta32; chemr13; CKR5; CKR-5; CMKBR5; HIV-1 fusion coreceptor; IDDM22; mutant C-C motif chemokine receptor

Rabbit

IgG

C-C chemokine receptor type 5

Human, Primate

-20°C,2°C to 8°C

12352203