Anti-CCR5 [T21/8]

Absolute Antibody

Anti-CCR5 [T21/8]

9

T21/8 antibody binds with high affinity to a CCR5 N-terminal epitope. CCR5 is a receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES.

T21/8 antibody is recommedned for the detection and analysis of CCR5 via various methods. For instance, one group used this antibody to detect intracellular localization of CCR5 in RBL-CCR5 cells via immunofluorescence staining (Pollok-Kopp et al., 2003). Another group investigated ligand-mediated down-modulation of CCR5 via flow cytometry, utilizing T21/8 antibody (Fox et al., 2015). With other anti-CCR5 antibodies which react with CCR5 phosphorylated on different serine residues (Ab01578; Ab01579), it can be used to study dynamic regulation of CCR5 and phosphorylation mechanisms.

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA

Research Use Only

Monoclonal

T21/8

CCR5

C-C motif chemokine receptor 5

C-C chemokine receptor type 5; C-C motif chemokine receptor 5 A159A; CCCKR5; CC-CKR-5; CCR-5; CD195; chemokine (C-C motif) receptor 5; chemokine receptor CCR5; chemokine recptor CCR5 Delta32; chemr13; CKR5; CKR-5; CMKBR5; HIV-1 fusion coreceptor; IDDM22; mutant C-C motif chemokine receptor

Human

IgG1

C-C chemokine receptor type 5

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203