anti-CD106 / VCAM1 antibody [STA]

Arigo Biolaboratories

anti-CD106 / VCAM1 antibody [STA]

23

Flow Cytometry, ImmunoPrecipitation, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Other Application

Research Use Only

Monoclonal

STA

1 mg/ml

Unconjugated

>95%

VCAM1

vascular cell adhesion molecule 1

CD106; CD106 antigen; INCAM-100; vascular cell adhesion protein 1

Mouse

IgG1

CD106 / VCAM-1 (vascular cell adhesion molecule-1) is an Ig-like cell surface adhesion molecule binding VLA-4 integrin. VCAM-1 is a potent T cell costimulatory molecule taking part in their positive selection and survival, as well as in adhesion, transendothelial migration and activation of peripheral T cells. VCAM-1 is also involved in endothelial cell-cell contacts. Whereas VCAM-1 normally mediates leukocyte extravasion to sites of tissue inflammation, tumour cells can use overexpressed VCAM-1 to escape T cell immunity. Soluble form of VCAM-1 (sVCAM-1) is an inflammatory marker and can be used also in prognosis of subsequent cariovascular events following acute coronary syndromes.

Human

-20°C

12352203