anti-CD107a / LAMP1 antibody [LY1C6]

Arigo Biolaboratories

anti-CD107a / LAMP1 antibody [LY1C6]

23

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

LY1C6

Unconjugated

Lamp1

lysosomal-associated membrane protein 1

120 kDa lysosomal membrane glycoprotein; CD107 antigen-like family member A; LAMP-1; LGP120; LGP-120; Lysosomal associated membrane protein 1 (120 kDa); lysosomal membrane glycoprotein 1; lysosome-associated membrane glycoprotein 1; lysosome-associated membrane protein 1

Mouse

IgG1

Lysosome-associated membrane proteins(LAMP1 and LAMP2) are major constituentsof the lysosomal membrane. These twoproteins have closely related structures with37% sequence homology. Both aretransmembrane glycoproteins localizedprimarily in lysosomes and late endosomes.Upon cell activation, rapid translocation ofintracellular LAMPs to the cell membrane isdependent on a carboxyl-terminal tyrosinebasedmotif (YXXI). Disruption of thespacing between the tyrosine-based motifabolishes lysosome localization of LAMP1,and the altered protein cycles between themembrane and the endosome. Cell surfaceLAMP1 and LAMP2 promote adhesion ofhuman peripheral blood mononuclear cells(PBMC) to vascular endothelium whichsuggests that they are involved in adhesionof PBMC at sites of inflammation.

Rat

-20°C

12352203