Anti-CD112 [Nec1-803-2]

Absolute Antibody

Anti-CD112 [Nec1-803-2]

9

This antibody binds an epitope between amino acids 47-142 of the human CD112 (Nectin-2) and does not cross reacts with cynomolgus monkey CD112. It is also capable of binding G113R and H128R mutants of human CD112. Nectin-2 acts as a modulator of T-cell si

The binding of this antibody to CD112 or Nectin-2 expressed on the surface of CHO cells was determined using whole cell ELISA. The reactivity of this antibody for human CD112 expressed on CHO-K1 cells was checked using flow cytometry. This antibody shows good ADCC activity against OV-90 human ovarian cancer cell lines. The in-vivo anti-tumor activity of this antibody was checked in nude mice models subcutaneously-transplanted with the OV-90 human ovarian cancer cell line (US20100008928).

Functional Assay, Flow Cytometry, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

Nec1-803-2

NECTIN2

nectin cell adhesion molecule 2

CD112; herpesvirus entry protein B; HVEB; nectin-2; poliovirus receptor-like 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); PRR2; PVRL2; PVRR2

Mouse

IgG2b

Nectin-2

This is a reformatted mouse IgG2b Fc Silent™ antibody, based on the original mouse IgG1 format, created for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203