Anti-CD112 [Nec8-4116-8]

Absolute Antibody

Anti-CD112 [Nec8-4116-8]

9

This antibody binds human CD112 (Nectin-2) and cross reacts with cynomolgus monkey CD112. It is also capable of binding AN77-78PD, G113R and H128R mutants of human CD112. Nectin-2 acts as a modulator of T-cell signaling. It can be either a costimulator of

The binding of this antibody to CD112 or Nectin-2 expressed on the surface of CHO cells was determined using whole cell ELISA. The cross reactivity of this antibody for cynomolgus monkey CD112 expressed on CHO-K1 cells was checked using flow cytometry. This antibody shows good ADCC activity against OV-90, MDA-MB-231, NCI-H1299, Du145 and U937 cell lines. The in-vivo activity of this antibody was checked in SCID mouse models for treating lung metastasis with MDA-MB-231 human breast cancer cell line and nude mice models for treating liver metastasis with OV-90 human ovarian cancer cell line (US20100008928).

Functional Assay, Flow Cytometry, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

Nec8-4116-8

NECTIN2

nectin cell adhesion molecule 2

CD112; herpesvirus entry protein B; HVEB; nectin-2; poliovirus receptor-like 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); PRR2; PVRL2; PVRR2

Mouse

IgG2b

Nectin-2

Human

-20°C,2°C to 8°C

12352203