Anti-CD115/M-CSFR [AFS98]

Absolute Antibody

Anti-CD115/M-CSFR [AFS98]

9

This antibody recognises mouse M-CSFR (CD115, CSF-1R) which is a membrane protein that influences tissue macrophage and osteoclast differentiation and proliferation.

AFS98 has been widely used in various flow cytometric analyses to label CD115 antigen. For instance, one group used it to detect monocytes in a mouse blood sample (Buschor et al., 2019). Similarly, Huo and colleagues (2017) utilised this antibody to identify monocytes in mouse blood in order to assess whether myelopoiesis was not a cause of the increase in the monocytes number. This antibody has been also successfully used to deplete macrophages (Ho et al., 2016). Finally, it was also utilised in the immunofluorescence staining of tissue sections prepared from 4% paraformaldehyde-fixed and decalcified bones (Dong et al., 2016).

Flow Cytometry, Western Blot, ImmunoHistoChemistry, Neutralisation/Blocking

Research Use Only

Monoclonal

AFS98

Csf1r

colony stimulating factor 1 receptor

AI323359; CD115; c-fms; Csf; CSF-; CSF-1 receptor; CSF-1R; CSF-1-R; Csfmr; Fim; Fim-; Fim2; Fim-2; Fm; Fms; macrophage colony-stimulating factor 1 receptor; M-CS; M-CSFR; M-CSF-R; proto-oncogene c-Fms; proto-oncogene fms

Mouse

IgG2a

Macrophage colony-stimulating factor 1 receptor

This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Mouse

12352203